High Blood Pressure Research Council of Australia

 

 

HBPRCA Email Newsletter

March 2008

 

Welcome to the first e-news for the year. Hopefully everyone has recovered from grant writing and can now focus on the real world.  We have a bumper issue with our new executive line up taking up their new roles in our 30th anniversary year.  

 

There are a number of new initiatives including our new look web site, a French Australian exchange initiative, our HBPRCA 30th Birthday Celebrations, an Ambulatory Blood Pressure Monitoring Initiative and a Human and Animal Devices workshop to accompany the end of year meeting.

 

For those that wish to relive the revelries of the Adelaide meeting, Athina from Meetings First has made a photo album available – click here.

 

Don’t forget that ISH is in Berlin this year, with registration and accommodation booking now open. Visit the website!

 

Associate Professor Geoffrey A Head

 

 

PRESIDENT’S MESSAGE from Stephen Harrap

It is an Honour to be able to continue to write under the President’s by-line and it is a delight to have a new Executive of the Council to carry on the great work of the previous. The new committee comprises:

 

Stephen Harrap

President

Geoff Head

Secretary

Brian Morris

Treasurer

Kate Denton

Program Secretary

Doug McKitrick

Membership Secretary

Marcus Schlaich

Program Secretary Assistant and Education Liaison

Louise Burrell

Corporate Liaison

Ann Goodchild

Student Liaison

Louise Burrell

Brian Morris

Bruce Neal

Society Liaison

 

 

Arduino Mangoni

Clinical Liaison

 

 

 

I’d like to thank all those who put themselves forward for the Executive and welcome and congratulate Ann Goodchild, Arduino Mangoni, Bruce Neal and Markus Schlaich, who have already shown their enthusiasm and potential to contribute.


I must also thank again the retiring members of the Executive: Jaye Chin-Dusting, Karen Duggan, Enzo Porrello, Malcolm West and Lindon Wing, each of whom did such a marvellous job in their own portfolios and for the Executive as a whole.


You will see below, that we are down to business already. In between grant writing and preparing for students we have been setting up the French Connection and making plans for our 30th Annual Scientific Meeting in Melbourne this year. This will be special!


I should mention that World Hypertension Day is coming in mid-May and one of the tasks that the Council has set itself is an attempt to bring together like-minded bodies – academic, professional, commercial & community – to plan for means of raising the public and government interest in high blood pressure. This year on or around World Hypertension Day we hope to host a relatively informal meeting between such groups to see if we can’t generate a sense of common purpose and develop some simple but potentially effective means of achieving our goals. I’m grateful to Bruce Neal who is giving our strategy his expert touch. We’d certainly be interested in hearing from any members of Council who might like to be involved in this endeavour or might have good ideas.

 

 

 

 

from Bruce Neal

I am delighted to take on the role of Inter-Society liaison for the High Blood Pressure Research Council.  My current position is as a Senior Director at the George Institute in Sydney where I lead a clinical and public health orientated vascular research group.  My particular areas of interest are large-scale clinical trials, observational studies and overview projects.   Most recently I have been working closely with colleagues in China and India to establish new initiatives addressing the huge burden of blood pressure-related diseases in those countries. While I bring a different background to this post I have strong international linkages and I will strive to provide the same value as my predecessor. 

 

 

 

 

from Markus Schlaich

As a German trained and board certified physician in internal medicine, nephrology and hypertension I have relocated permanently to Melbourne in November 2006 to take up a position as a clinical scientist at the Baker Heart Research Institute and the Alfred Hospital. My interests are in various facets of high blood pressure both clinically and scientifically with a particular focus on the sympathetic nervous system and the involvement of the kidneys. I have been an active member of the German and European Society of Hypertension for several years both with regards to scientific and educational contributions. In my new role within the HBPRCA I will build on these aspects and on my strong and ongoing ties with both the German and the European Societies of Hypertension to support the goals and initiatives of the HBPRCA and its members and to foster international collaborations and strategies to reduce the burden of hypertension. I would like to take the opportunity to thank the members for their votes and I am looking forward to working in this inspiring environment.

 

 

 

 

from Ann Goodchild

My new role on council is student liaison. I have recently moved to the Australian School of Advanced Medicine, a newly established facility at Macquarie University where my research focus is brainstem control of peripheral vasculature and the heart. My particular interest is to understand the role intracellular signaling pathways play in maintaining the activity of neurons in health and how these are altered in hypertension. I hope to encourage greater student participation and promote stronger interaction with non-student members in the society. Please feel free to contact me with any ideas.

 

 

 

from Arduino Mangoni

I am very pleased to take on the role of Clinical liaison for the High Blood Pressure Research Council. I'm currently Associate Professor in Clinical Pharmacology and Senior Consultant in Clinical Pharmacology and General Medicine at Flinders University and Flinders Medical Centre. My research interests include endothelial function, arterial mechanical, and neuro-hormonal control in hypertension, chronic kidney disease, and heart failure. I have a strong clinical training background in Cardiology, Clinical Pharmacology and General Medicine and I will try my best to serve the Council in the most productive manner.

 

 

MEETING NEWS from Kate Denton

The wheels are in motion for putting together this year’s annual meeting. Invitations for the keynote lecturers have been sent out and I’m pleased to announce that the 2008 RD Wright Lecturer is Professor Carlos Ferrario (MD FAHA, FASA, FACC) from Wakefield University in the USA.  His research spans basic and clinical investigations, focusing on hypertensive vascular disease with a particular interest in the vascular actions of angiotensin peptides.  Professor Ferrario was honoured to accept the invitation and will I’m sure be willing to visit laboratories during his stay in Australia.  Anyone interested in extending an invitation to Carlos, should contact me, as we need to establish these plans early, as it is difficult to organise after travel plans have been finalised. 

 

The Austin Doyle lecturer is an expatriate, Associate Professor David Sinclair, Harvard Medical School.  David did his PhD with Prof Dawes in Sydney. His research focuses on ways to prevent and treat the major diseases of society by manipulating genes that control how fast we age. All reports suggest that David is an engaging speaker. Certainly, his work has been recognized by many prestigious awards and invitations. We are fortunate that he has been able to accept our invitation this year.

 

I am also particularly please to announce that our own Assoc Prof Bruce Neal has accepted the Colin Johnston lectureship.  An award that he is well suited for, having risen in a very short time to be to be head of a very large cardiovascular research group at The George Institute in Sydney, where he is now a Senior Director of Vascular Research. Bruce Neal is a cardiovascular epidemiologist with particular expertise in the conduct of large-scale studies in the field of blood pressure and cardiovascular diseases, focusing on providing new evidence to influence clinical practice. Some of his major contributions to date include being study director and member of the Management Committee for the PROGRESS and ADVANCE trials, being one of the Founders of and the Director responsible for the Blood Pressure Lowering Treatment Tribalists’ Collaboration, and accepting a major role as Chairman of the Australian Division of World Action on Salt and Health (AWASH) which he has energised to a remarkable degree. Bruce has been at the forefront of moving away from basing treatment decisions purely on the level of blood pressure per se to basing them on total cardiovascular risk.  This has extended the indications for treatment to include blood pressure lowering in individuals with high cardiovascular risk, but with blood pressure in the “normal range.  I’m sure that he will deliver a talk of interest to all our members.

 

I also have plans to try (yet again!) to energise the poster sessions.  I would like to engage the help of our more junior post-doc members in awarding some smaller prizes to poster presentations.  This will not replace the student poster prize.  However, this will give valuable experience to our younger colleagues, be an addition to their CV’s and will hopefully involve greater participation in the poster discussions.

 

Human and Animal Devices Workshop

This years workshop which will be held on Wednesday 3rd of December prior to the main meeting and will be focussed on devices used in both clinical and basic (animal) research. Data Sciences International are keen to continue to sponsor the animal telemetry users component of the workshop which proved to be very successful in Brisbane. We have also had considerable interest in expanding this to include human devices. The workshop will therefore be organised as a morning and afternoon sessions focussing on each area, which will allow participants to attend either or both sessions depending on their interests.

 

If any members would like to contribute please contact the organising committee Geoff Head, Kate Denton, Markus Schlaich and Arduino Mangoni via hbprca@meetingsfirst.com.au.

 

 

HBPRCA 30TH BIRTHDAY CELEBRATIONS

 

Student introductions

Getting to know and encouraging the next generation of leaders in BP research is a major goal of the Council. Therefore, we thought that it would be a good idea to “introduce” our students at this year’s annual dinner. We would like to do this in the form of a power point presentation that will loop for most of the night. We are requesting that students provide the secretariat with their photo and some salient points about themselves (no more than 50 words). This will help put names and interests to student faces and facilitate convivial conversations.

 

Our Family Tree

We’d like to take the opportunity of the 30th Anniversary to try and construct a “Family Tree” of blood pressure research in Australia. To do so we’d like all our members to indicate the person who had the greatest direct influence in shaping your career in blood pressure research. You might have more than one perhaps (perhaps one scientific and one clinical) but please limit your nominations to 2 maximum. Even if you trained overseas let us know your names as we might find branches of the “family” extend around the world.

 

 

Competitions

We would like to open the following four competitions – 2 written and 2 photographic:

Best research meeting destination story – One of the joys of research is travel and discovering sites and places that amaze and enthrall. What has been your best meeting destination and why was it so special?

Best travel nightmare story – On the other hand one of the horrors of research can be travel! Sometimes getting there and back is enough to make you cry. Tell us when you wished you’d never left home for a BP meeting and share the gory details.

Best photograph taken by a member – Some members are well known for their photographic prowess, but we suspect that there are some other excellent photographers amongst us. Have you a photograph that makes you proud? Then we’d love to see it. You might even win a prize. The picture can be anything, even some beautiful images generated by your research or a picture of your pet!

Best photograph of a member – In this category, photographs are restricted to images of members (present and past).

 

Please be sure to get permission from the member before submitting, as we will be following this up!

 

PRIZES at the ASM

We have updated the “prize” definitions, to make them simpler for all. Please see below.  This information is also on the website.

 

Early Career Investigator Oral and Poster Awards

Supported by the High Blood Pressure Research Council of Australia (oral)

Supported by Clinical Science (poster)

 

This award is to encourage membership and foster active participation of early career investigators in the HBPRCA. The candidate must be an early career scientist (up to 10 years post-doctorate, with consideration given for career interruption).

 

Student Oral and Poster Presentation Awards

Supported by the High Blood Pressure Research Council of Australia


The candidate must be a student currently enrolled in an Honours, Masters or PhD program in a field relevant to the award. The goal of this prize is to encourage membership and foster active participation of enrolled scholars in the HBPRCA. 

 

Prizes and Eligibility

All finalists are selected based on the ranking of their abstracts submitted by the normal process for presentation at the Annual Scientific Meeting of the Council. The winner of each prize will be decided by an specially convened judging panel based on the quality of the data and the presentation.


In order to be eligible for any of the awards listed above, you MUST:

be a member of the HBPRCA by September 30 in the year of application to qualify.

be the first author of the abstract

NOT have published the work presented in the abstract in other than electronic form, at the time of submission.

NOT to have won an award in same category in the previous year*.

 

Best Oral Prizes of $1,000 – will be awarded to the best presentation in the Early Career Investigator Oral Award Finalists Session and also to the best Student Oral Presentation.

Best Poster Prizes of $500 will be awarded to the best Early Career Investigator presentation and also to the best student presentation. In each case the presentation will involve the poster and a mini oral presentation. The Early career Investigator award is sponsored by Clinical Science and includes a certificate and a year's free online access to Clinical Science.  

 

British Hypertension Society Award

Supported by the High Blood Pressure Research Council of Australia and the British Hypertension Society (BHS)


This is single award to the highest scoring presentation from either the Early Career Investigator Oral Award Finalists or the Student Oral Presentation Award Finalists. It is underlines the society's strong alliance with the BHS. The prize is a formal invitation to attend and present at the following BHS Annual Scientific meeting in September. The award comprises an amount of $2,500 towards travel expenses. Accommodation will be provided by the BHS during the meeting in the UK. This money is in addition to the $1,000 received as either the Early Career Investigator Oral winner or the Student Oral Presentation Award winner. The recipient is also expected to visit laboratories with like research interests before or after the meeting. The winner is not eligible for this award in the following year.


*If you won the poster or oral prize last year you are not eligible for the poster or oral prize in this year in the same category. A student winner who becomes a full member of the Council is eligible for the ECI award the following year.

 

 

MEMBERSHIP NEWS from Doug McKitrick

March 31st is the annual subscription due date for the HBPRCA. If you have thus far overlooked paying it’s still not too late! Simply go to the HBPRCA website (www.meetingfirst.com.au) and follow the link on the left for access to the secure payment site or to download a form for return by post. If you don’t have internet access, can’t remember if you have paid, or just need a bit of help, contact the secretariat by phone, fax or post (details below).

 

Don’t forget to encourage your graduate students and post docs to take out membership with the Council (free for students!). The special initiatives that have been introduced are specifically intended to benefit student and early career members. And of course participating in the vibrant Annual Scientific Meeting (particularly the 2008 30th anniversary meeting) is a tremendous opportunity for you, your post-docs, students and research associates to see and discuss the broad research interests of the council and share your own.

 

 

FRANCO AUSTRALIAN EXCHANGE PROGRAM from Geoff Head and Bruce Neal

We are delighted to announce a joint initiative of the HBRPCA and our French counterparts Société Française d’Hypertension Artérielle  (SFHTA) in which we will provide financial support (for airfare and accommodation) for members wishing to spend a short (1-3 month) work in a laboratory in each other’s country. Initially the exchange program will sponsor one person each way, fostering collaborative projects between French and Australian Hypertension researchers. There are no age limits or prerequisites apart from being a member of either group, gaining the agreement of the host laboratory and making an application in writing to the French Society (for the French applicants) and to the HBPRCA for the Aussies. A description of the project to be undertaken and an indication as to how the proposed exchange program will be beneficial to the success of the research initiative should be outlined. 

·          Application forms are available from Meetings First, hbprca@meetingsfirst.com.au

·          The deadline for applications will be the 25th of April (Anzac day). The applications will be judged by a panel of the HBPRCA executive and notification expected to be made within 2 weeks of the application.

·          The degree of support is anticipated to be AUD$2500 toward the airfare and 800-1000 euros per month towards the cost of accommodation.

·          The winner will be required to write a feature article (in English) with photos for the e-news!!

 

 

AMBULATORY BLOOD PRESSURE MONITORING (ABPM) WORKING GROUP INITIATIVE 2008

At present ABPM can be used to diagnose hypertension, but cannot be used to manage hypertension because there are no ABPM equivalents for target BP.  While the PAMELA (1) study provided an ABPM equivalent for the diagnostic level of 140/90, this study from Monza in Italy does not readily provide ABPM equivalents for target BP’s such as 125/75, nor is it necessarily relevant to the Australian population.  It is therefore important to derive a robust algorithm, which can provide relevant ABPM target blood pressures. 

 

This HBPRCA clinical research collaborative initiative is to establish ABPM target blood pressures relevant to the Australian population. A number of Council members have expressed interest in participating in the Working Group and we would like to hear from more members who have experience in ambulatory recording and would like to contribute their data so that we can collect clinic blood pressure and ambulatory recordings throughout Australia in order to provide sufficient data to derive the Clinic- ABPM relationship which will also be able to account for ethnicity, sex or age. We are currently preparing the project outline and scope for agreement and welcome suggestions.

 

To indicate the feasibility of this process, we have performed an initial pilot analysis of data collected at the Alfred-Baker Heart centre. Figure below left shows the correlation between 24 hour and Clinic Systolic Blood Pressure, which has regression coefficients very close to the PAMELA study. The table (below right) indicates the equivalent ABPM values for the clinic values of 140/90 based on the regressions. Interestingly, the PAMELA study and our pilot data show for at least 24 hour measurements, almost identical results.

 

Pamela Study (n=1600)

 

Clinic

24Hr

Daytime

Nighttime

SBP

140

123

128

112

DBP

90

77

82

67

Aussie Pilot Data (n=600)

 

Clinic

24Hr

Daytime

Nighttime

SBP

140

123

132

118

DBP

90

78

83

71

 

We are working to have this completed by the end of the year so we would expect data collection to be complete by June this year. In order to promote further participation, some details of the data to be collected is set out below.

 

The data will need to be de-identified and its inclusion in the analysis will need the respective Institution Ethics Committee approval for transfer. The data will include the following:

 

 

Clinic SBP Standing

Clinic SBP Sitting

Clinic SBP lying

Age

Clinic DBP Standing

Clinic DBP Sitting

Clinic DBP lying

Sex

Clinic Heart rate Standing

Clinic Heart rate Sitting

Clinic Heart rate lying

Height (optional)

ABPM 24hr SBP

ABPM 24hr DBP

ABPM 24hr HR

Ethnicity

ABPM Day SBP

ABPM day DBP

ABPM day HR

BMI (optional)

ABPM Night SBP

ABPM Night DBP

ABPM Night HR

Antihypertensive treatment
yes or no

 

We now need to know those council members that would like to participate in this project. Now is the time to get on board! Please contact geoff.head@baker.edu.au by COB Friday 4 April 2008.

 

Mancia G, Sega R, Bravi C, De Vito G, Valagussa F, Cesana G, Zanchetti A. Ambulatory blood pressure normality: results from the PAMELA study. J Hypertens. 1995;13:1377-1390.

 

 

CALL FOR SPECIAL ARTICLES for Hypertension

Professor John hall has written to members of the Council who are editors of Hypertension and asked for suggestions for invitations to write articles on specific topics and for potential authors who should be invited to write Brief Reviews, Hypertension Highlights, and other features that would be of exceptional interest to the readers of Hypertension. These features are described on the web site for Hypertension at: http://hyper.ahajournals.org/

 

If you are interested in contributing, please contact Stephen Harrap s.harrap@unimelb.edu.au or other Hypertension board members who are members of the Council.

 

 

DR RALPH READER from Paul Korner

Dr Ralph Reader (Fig 1 nearby, see legend), who was the first Director of the National Heart Foundation of Australia, died in Canberra on