August, 2005



As Spring fast approaches (tomorrow), we all realise that the end of the year is near. Hopefully the studies and trials are all going to plan and I know everyone is eagerly awaiting the opening of the abstract submissions (very shortly) for the HBPRCA annual Scientific meeting. This year will be one not to be missed, especially for STUDENTS as there is the fantastic prospect of winning a trip to the United Kingdom to present at the British Hypertension Society (See Kate’s section). To celebrate these new links, we feature an article on the British Hypertension Society. In addition, we highlight the work of Professor A F Dominiczak from Glasgow, who is an active member of the BHS and who has been invited to be the RD Wright Lecturer for 2005 at this year’s ASM (see feature article). Many of you may be surprised by our magnanimous nature in face of our disastrous Ashes tour (Cricket).

Happy reading.




PRESIDENT’S MESSAGE from Stephen Harrap

The Annual Scientific Meeting is drawing nearer and shortly you will be receiving all the information for registration and abstract submission. This will be a very special meeting for us all and one that we hope will provide both stimulus and opportunity for the Council to grow stronger. If you have not been to the ASM for a year or two, now is the perfect time to renew your involvement and catch up with old and new colleagues and friends. We would also be grateful for your help by encouraging others to participate and hopefully join the Council. This is especially true for students, for whom there are significant advantages in joining our ranks.



High Blood Pressure Research Council 27th Annual Scientific Meeting

Wednesday 7th December 2005 for the Clinical Workshop starting at 4:30 pm.

Thursday-Friday 8-9th December for the Main Scientific meeting Bio21, 30 Flemington Road, Carlton Victoria 3053 Australia.




MEMBERSHIP NEWS from Doug McKitrick


Do your graduate students know that they can have free membership in the HBPRCA? Do your post-docs know of the networking opportunities and broader scientific community involvement that come with HBPRCA membership? Do you have a colleague that contributes to hypertension research, treatment or education that would benefit from HBPRCA membership, and have you talked to them about it? Have you renewed your membership in Australia’s premier society for hypertension-related research and information? If it’s all ‘YES’ jump ahead to the next section and read on. If its some ‘NO’s or ‘DON’T KNOW’s please take a few minutes and make a plan. Feel free to contact us for advice.


If you have specific comments or concerns with your membership, or issues relating to membership generally, accept the invitation to communicate them directly to the Membership Secretary, Dr Doug McKitrick, via contact details available on the HBPRCA website.






SOCIETY NEWS from Kate Denton


Great news regarding our plans to establish closer links with the British Hypertension Society. The proposal put forward, was that the top student (as judged each year on the basis of abstract and oral presentation) from each society would be supported to attend the reciprocal society’s next annual meeting and present their work. The student would be expected to visit a number of laboratories in the UK and to establish relationships that we hope would flourish over time BHS has taken up this proposal with enthusiasm and are prepared to send their student prize winner to our meeting in December this year. Therefore our student would attend the BHS meeting in September 2006.
All members should encourage their students to become members of the society and submitted abstracts to this years meeting. This award will be advertised in detail in the forthcoming call for abstracts for the HBPRCA 2006 meeting. We hope to see many student submissions this year, to take advantage of this opportunity to enhance their international research profile.




August Feature Articles


The British Hypertension Society


The British Hypertension Society (BHS) is a society much like our own with over 230 members formed with the aim to promote the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial hypertension and related vascular diseases with in the United Kingdom. They provide a medical and scientific research forum to enable sharing of cutting edge research in order to understand the origin of high blood pressure and improve its treatment. 

The BHS formed in the early 1980’s has a strong track record of producing internationally renowned guidelines for the management of hypertension which are widely adopted in primary care in the UK and elsewhere.  As part of our increasing engagement in improving blood pressure measurement they are now undertaking active validation of new blood pressure devices for the measurement of blood pressure. The Society has also established an educational programme to support scientists, doctors and other healthcare workers involved in understanding the basis of high blood pressure and improving its treatment throughout the UK.  The BHS has a number of initiatives which are organised by Working Parties who report to the Executive Committee. The BHS Information Service and Guidelines Working Party (Chair: Professor Bryan Williams) provides information for health care professionals about hypertension (BP Measurement CD-ROM and Posters, Nurse Distance Learning Packs, ABCD Algorithm Posters, BHS Cardiovascular Medicine Research Net, Shared Care Card, Factfiles). The BHS Educational Programmes Working Party (Chair: Professor Mark Caulfield) develops and implement BHS Live! Events, supervises the organisation of UK Specialist Accreditation, BHS Primary Care Meetings and Masterclasses. The BHS BP Monitoring Working Party (Chair: Professor John Potter) advises on the validation of blood pressure monitors and is responsible for issues relating to mercury.


The Annual Scientific meeting of the British Hypertension Society.


One of their main activities is there an annual scientific meeting which is held every September at a University Campus in the UK and Ireland. This year the ANNUAL SCIENTIFIC MEETING will be at historic Queens’ College, Cambridge on Monday 19th September until Wednesday 21st  September 2005.  The meeting secretary is Mrs Gerry McCarthy (Hampton Medical Conferences Ltd,

Photo Left: A Cambridge Wooden Bridge in winter - built in 1749 by James Essex the Younger.





The  SIR GEORGE PICKERING LECTURE will be given by past president Professor Graham MacGregor (London) “Salt – Neptune’s Gift?”  Professor Macgregor as chairman of the “Group Consensus Action on Salt and Health”  has been leading a strong public campaign to reduce the salt content of British foods.

Other highlights of the meeting will be a session on ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) entitled “Are there Implications for the BHS/NICE Treatment Algorithms?”


Photo Left: Old Hall, Cambridge, built in 1449.



The British Hypertension Society Executive

The BHS current president is Professor Neil R. Poulter (photo left) who is the Professor Preventive Cardiovascular Medicine at Imperial College School of Medicine National Heart and Lung Institute, London. (email ).







The BHS Vice-President is Professor Morris J. Brown (photo left) who is a principal investigator at the Clinical Pharmacology Unit, a division of the Department of Medicine in the University of Cambridge (Cambridge,


The BHS Secretary is Professor Alun D. Hughes, Professor of Clinical Pharmacology (Imperial College,





Past presidents include Dr. J. Robertson, Dr. J. Ledingham, Professor John Reid, Professor Peter Sever, Professor A. Lever , Professor Peter Sleight , Professor D.G. Beevers , Professor L.E. Ramsay,  Professor Graham MacGregor and Professor B. Williams.


August Feature Article Part 2 : RD Wright Lecturer for 2005


Professor A F Dominiczak


Professor A F Dominiczak MD FRCP FmedSci, from the UNIVERSITY OF GLASGOW, Western Infirmary holds a British Heart Foundation Chair of Cardiovascular Medicine.  Anna graduated in Medicine at the Medical School of Gdansk, Poland in 1978 and currently heads the BHF Blood Pressure Group at the University of Glasgow. She is also a Consultant Physician and Endocrinologist at the Western Infirmary and Associate Dean for Research at the Faculty of Medicine. She has a major research interest in cardiovascular genetics and vascular biology; and holds a BHF Programme Grant “Genetic determinants of hypertension and its vascular complication: from positional candidate genes to vascular gene transfer strategies”

Her Research interests fall into 3 main areas

Molecular genetic strategies in cardiovascular and cerebrovascular disease. Designed to unravel the susceptibility and severity genes for blood pressure regulation, left ventricular hypertrophy and the sensitivity to cerebrovascular ischaemia in a stroke prone spontaneously hypertensive model. She l uses quantitative trait loci identified in experimental studies to guide the genetic analysis of human cardiovascular and cerebrovascular disease.
Endothelial function in vessels. These studies focus on a hypothesis that one of the major modifiable determinants of endothelial dysfunction is an imbalance between the nitric oxide and the superoxide anion. Her team has demonstrated that the nitric oxide-dependent endothelial dysfunction in vessels is due to excess of superoxide anion generated by the endothelium. These studies are currently being translated from bench to bedside with the use of a non-invasive vascular ultrasound technique.


Vascular gene transfer strategies. Targeted gene transfer strategies have been designed to restore the nitric oxide/superoxide balance in the HRSP in vivo and in human saphenous veins ex vivo. Her group have developed viral vectors based on recombinant adenoviruses encoding bovine and human endothelial nitric oxide synthase genes and demonstrated high levels of foreign gene expression associated with a significant improvement of endothelial nitric oxide bioavailability in functional studies. Further work in this area will address similar strategies in human vessels as well as new viral vectors and new cDNA constructs to address more thoroughly the issue of local molecular therapeutic strategies.


She has published over 160 publications including these recently:


1.         Carswell HV, McBride MW, Graham D, Dominiczak AF, Macrae IM. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Methods Mol Med. 2005;104:49-74.

2.         Tomaszewski M, Charchar FJ, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Letter re: Inflammation and lipoprotein changes with protracted exercise. J Clin Endocrinol Metab. 2005;90:4981.

3.         Miller WH, Brosnan MJ, Graham D, Nicol CG, Morecroft I, Channon KM, Danilov SM, Reynolds PN, Baker AH, Dominiczak AF. Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Mol Ther. 2005;12:321-7.

4.         Graham D, McBride MW, Brain NJ, Dominiczak AF. Congenic/consomic models of hypertension. Methods Mol Med. 2005;108:3-15.

5.         Nemoto K, Sekimoto M, Fukamachi K, Kageyama H, Degawa M, Hamadai M, Hendley ED, Macrae IM, Clark JS, Dominiczak AF, Ueyama T. No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats. Hypertens Res. 2005;28:155-63.

6.         Brain N, Jr., Dominiczak AF. Pharmacogenomics in hypertension: present practicalities and future potential. J Hypertens. 2005;23:1327-9.

7.         Carswell HV, Dominiczak AF, Garcia-Segura LM, Harada N, Hutchison JB, Macrae IM. Brain aromatase expression after experimental stroke: Topography and time course. J Steroid Biochem Mol Biol. 2005;96:89-91.

8.         Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M, Munroe PB. Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet. 2005;14:1805-14.

9.         McCallum RW, Sainsbury CA, Spiers A, Dominiczak AF, Petrie JR, Sattar N, Connell JM. Growth hormone replacement reduces C-reactive protein and large-artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency. Clin Endocrinol (Oxf). 2005;62:473-9.

10.       Collison M, James DJ, Graham D, Holman GD, Connell JM, Dominiczak AF, Gould GW, Salt IP. Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia. 2005;48:539-46.

11.       Dominiczak AF, Graham D, McBride MW, Brain NJ, Lee WK, Charchar FJ, Tomaszewski M, Delles C, Hamilton CA. Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension. 2005;45:636-42.

12.       McBride MW, Brosnan MJ, Mathers J, McLellan LI, Miller WH, Graham D, Hanlon N, Hamilton CA, Polke JM, Lee WK, Dominiczak AF. Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension. 2005;45:786-92.

13.       McCallum RW, Hamilton CA, Graham D, Jardine E, Connell JM, Dominiczak AF. Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats. J Hypertens. 2005;23:351-8.

14.       McGill JK, Gallagher L, Carswell HV, Irving EA, Dominiczak AF, Macrae IM. Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke. 2005;36:135-41.


This months Feature Articles prepared by G A Head, August 2005






The Beilin Symposium will be held from 6th – 7th December 2005. Registrations are now open.

To view a copy of the invitation, please click here.

To obtain a registration form, please click here.

Please go to the Meetings First website for further information.




Clinical & Experimental Pharmacology and Physiology (CEPP) is Free to HBPRCA members

CEPP aims to make a substantial contribution to effective and productive communication between scientists throughout the world who are working in these interrelated disciplines. The journal provides a medium for the rapid publication of original research papers, short communications, rapid communications and theoretical articles (hypotheses) on the results of clinical and experimental work in pharmacology and physiology. Invited review articles are published occasionally.


To access the journal online visit and log in or register if you are a new user. Once you are logged in follow the three simple steps below:

       Click on the blue ‘My Synergy’ tab and the top of the screen and then click the blue ‘Access’ tab in the middle of the screen.

1.      Enter CEPHBPTRIAL2005 in the ‘Access Token’ box exactly as it appears here. You will only need to enter this code the first time you use Blackwell Synergy

2.       Now click ‘Continue’


You will have access to all content in CEPP every time you log in until 31st of December 2005.


Manuscripts can be submitted to CEPP via






Monash University are still running workshops in microscopy techniques.   If you are interested in attending, find out more by contacting the organisers or downloading a copy of the brochure.






ASMR needs your help during 2005, to ensure that medical research in our country remains competitive and translates to better health and economic outcomes for all Australians. You need to act now:

¨       Visit your local member twice in 2005.  Once before June and again before October.

¨       Before September, write to: your local member; the Health Minister; the Treasurer; the Prime Minister


Points of focus: (use examples from your field) Medical research is vital to Australia’s future, it,

®    underpins the health of all Australians

®    delivers exceptional returns on investment

®    creates knowledge-based jobs


Please click here to view information on the ASMR Campaign to increase Health and Medical Research Funding.





With best wishes,



A/Prof Geoffrey A. Head

HBPRCA Secretary





HBPRCA Secretariat

Meetings First

t           61 3 9739 7697

f           61 3 9739 7076





European Society of Cardiology

Annual Scientific Meeting

Stockholmsmässan, Stockholm, SWEDEN

Saturday, September 3 – Wednesday, September 7, 2005

Click here for the meeting website

Click here for the society website


Canadian Cardiovascular Society

Annual Scientific Meeting

Quebec, CANADA

Saturday, October 22 – Wednesday, October 26, 2005

Click here for meeting website

Click here for society website

American Heart Association

59th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease
Omni Shoreham Hotel - Washington, DC
Sep 21-24, 2005

Click here for the meeting website

Click here for the society website


American Heart Association

Scientific sessions
Dallas Convention Center - Dallas, TX
Nov 13-16, 2005

Click here for the meeting website

Click here for the society website


High Blood Pressure Research Council

27th Annual Scientific Meeting

Wednesday 7th December 2005 for the Clinical Workshop starting at 4:30 pm.

Thursday-Friday 8-9th December for the Main Scientific meeting

Bio21, 30 Flemington Road, Carlton Victoria 3053 Australia.

Click here for Meeting website and Society Web Page


ASMR National Scientific Conference

On Hormones, Fertility and Cancer

Couran Cove, Queensland

November 20-23 2005


Click here to view the Conference notice

Click here for society website

The Beilin Symposium

December 6-7, 2005

Alan Gilbert Building

University of Melbourne, Melbourne

Click here for Meeting website

Click here for the flyer

Asian Pacific Society of Nuclear Cardiology
Annual Scientific Meeting

Annual scientific meeting

Mumbai, INDIA

Thursday, December 1 – Sunday, December 4, 2005

Click here for meeting website

Click here for Asian Pacific Society of Nuclear Cardiology website





International Conference on Healthy Ageing and Longevity

3rd Annual Meeting

Friday, April 28 – Sunday, April 30, 2006

Melbourne Convention and Exhibition Centre – Melbourne, AUSTRALIA

Click here for meeting website


International Society of Hypertension

21st Scientific Meeting

Saturday, October 15 – Wednesday, October 19, 2006

Fukuoka International Congress Centre – Fukuoka, JAPAN

Click here for meeting website

Click here for International Society of hypertension web page

American Heart Association

Obesity, Lifestyle, and Cardiovascular Disease Symposium.

Grand Hyatt Washington - Washington, DC

Jan 18-20, 2006

Click here for the meeting website

Click here for the society website

American Stroke Association
A Division of American Heart Association

International Stroke Conference, Gaylord Palms, Kissimmee, Florida

February 16-18 2006

Click here for the meeting website

Click here for the society website


American Society of Hypertension

Annual meeting

New York City, Hilton Hotel
May 17-20, 2006

Click here for the meeting website

Click here for the society website

European Society of Cardiology

Heart Failure 2006

17 June 2006 - 20 June 2006
Helsinki, Finland
Click here for the meeting website
Click here for the society website


World Congress of Cardiology 2006  
2-6 September 2006 “Bringing together the European Society of Cardiology Congress 2006 and the World Heart Federation's XVth World Congress of Cardiology.”
Barcelona, Spain 
Click here for the meeting website
Click here for the society website